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Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator: the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders

Authors
Kim, M  | Han, JH  | Kim, JH  | Park, TJ  | Kang, HY
Citation
The Journal of investigative dermatology, 136(1). : 236-244, 2016
Journal Title
The Journal of investigative dermatology
ISSN
0022-202X1523-1747
Abstract
In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin. To investigate the effect of sFRP2 on melanogenesis, normal human melanocytes were infected with sFRP2-lentivirus or sh-sFRP2. It was found that sFRP2 stimulates melanogenesis through microphthalmia-associated transcription factor and/or tyrosinase upregulation via beta-catenin signaling. The stimulatory action of sFRP2 in pigmentation was further confirmed in melanocytes cocultured with fibroblasts and in ex vivo cultured skin. The findings suggest that sFRP2 functions as a melanogenic stimulator and that it plays a role in the development of UV-induced hyperpigmentary disorders.
MeSH

DOI
10.1038/JID.2015.365
PMID
26763443
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Ajou Authors
강, 희영  |  김, 미선  |  김, 장희  |  박, 태준  |  한, 재호
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