268 719

Cited 12 times in

Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome

Authors
Kang, JH  | Kim, YY | Chang, JY | Kho, HS
Citation
Archives of oral biology, 78. : 58-64, 2017
Journal Title
Archives of oral biology
ISSN
0003-99691879-1506
Abstract
OBJECTIVES: To investigate possible relationships among oral mucosal epithelial MUC1 expression, salivary female gonadal hormones and stress markers, and clinical characteristics in patients with burning mouth syndrome (BMS).
DESIGN: Thirty post-menopausal female patients with BMS (60.0+/-5.0 years) were included. Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed. The levels of cortisol, dehydroepiandrosterone (DHEA), 17beta-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) samples.
RESULTS: Salivary progesterone level had significant positive correlations with oral mucosal epithelial MUC1 expression level and with salivary cortisol and DHEA levels. The salivary level of 17beta-estradiol showed significant positive correlations with period of symptom duration, severity of effects of oral complaints on daily life, and results from psychological evaluations. Cortisol level in UWS and cortisol/DHEA ratio in UWS and SWS had negative correlations with severity of oral burning sensation significantly. The severity of taste disturbance had positive correlations with results from psychometry significantly.
CONCLUSION: Dysregulated psychoendocrinological interactions might affect oral mucosal MUC1 expression and severity of oral burning sensation in post-menopausal BMS patients.
MeSH

DOI
10.1016/j.archoralbio.2017.01.022
PMID
28199919
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
Ajou Authors
강, 정현
Files in This Item:
28199919.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse