19 29

Cited 2 times in

Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome

Authors
Kang, JH; Kim, YY; Chang, JY; Kho, HS
Citation
Archives of oral biology, 78:58-64, 2017
Journal Title
Archives of oral biology
ISSN
0003-99691879-1506
Abstract
OBJECTIVES: To investigate possible relationships among oral mucosal epithelial MUC1 expression, salivary female gonadal hormones and stress markers, and clinical characteristics in patients with burning mouth syndrome (BMS).
DESIGN: Thirty post-menopausal female patients with BMS (60.0+/-5.0 years) were included. Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed. The levels of cortisol, dehydroepiandrosterone (DHEA), 17beta-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) samples.
RESULTS: Salivary progesterone level had significant positive correlations with oral mucosal epithelial MUC1 expression level and with salivary cortisol and DHEA levels. The salivary level of 17beta-estradiol showed significant positive correlations with period of symptom duration, severity of effects of oral complaints on daily life, and results from psychological evaluations. Cortisol level in UWS and cortisol/DHEA ratio in UWS and SWS had negative correlations with severity of oral burning sensation significantly. The severity of taste disturbance had positive correlations with results from psychometry significantly.
CONCLUSION: Dysregulated psychoendocrinological interactions might affect oral mucosal MUC1 expression and severity of oral burning sensation in post-menopausal BMS patients.
MeSH terms
Burning Mouth Syndrome/metabolism*Burning Mouth Syndrome/psychologyDehydroepiandrosterone/metabolismEstradiol/metabolism*FemaleHumansHydrocortisone/metabolismMiddle AgedMucin-1/metabolism*Pain MeasurementPostmenopauseProgesterone/metabolism*Real-Time Polymerase Chain ReactionSaliva/chemistry*
DOI
10.1016/j.archoralbio.2017.01.022
PMID
28199919
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
AJOU Authors
강, 정현
Files in This Item:
28199919.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse