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Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome

Kang, JH; Kim, YY; Chang, JY; Kho, HS
Archives of oral biology, 78:58-64, 2017
Journal Title
Archives of oral biology
OBJECTIVES: To investigate possible relationships among oral mucosal epithelial MUC1 expression, salivary female gonadal hormones and stress markers, and clinical characteristics in patients with burning mouth syndrome (BMS).
DESIGN: Thirty post-menopausal female patients with BMS (60.0+/-5.0 years) were included. Clinical and psychological evaluations were performed and the expression level of oral mucosal epithelial MUC1 was analyzed. The levels of cortisol, dehydroepiandrosterone (DHEA), 17beta-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS) samples.
RESULTS: Salivary progesterone level had significant positive correlations with oral mucosal epithelial MUC1 expression level and with salivary cortisol and DHEA levels. The salivary level of 17beta-estradiol showed significant positive correlations with period of symptom duration, severity of effects of oral complaints on daily life, and results from psychological evaluations. Cortisol level in UWS and cortisol/DHEA ratio in UWS and SWS had negative correlations with severity of oral burning sensation significantly. The severity of taste disturbance had positive correlations with results from psychometry significantly.
CONCLUSION: Dysregulated psychoendocrinological interactions might affect oral mucosal MUC1 expression and severity of oral burning sensation in post-menopausal BMS patients.
MeSH terms
Burning Mouth Syndrome/metabolism*Burning Mouth Syndrome/psychologyDehydroepiandrosterone/metabolismEstradiol/metabolism*FemaleHumansHydrocortisone/metabolismMiddle AgedMucin-1/metabolism*Pain MeasurementPostmenopauseProgesterone/metabolism*Real-Time Polymerase Chain ReactionSaliva/chemistry*
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Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
AJOU Authors
강, 정현
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