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Choroidal Thickness Indicates Subclinical Ocular and Systemic Inflammation in Eyes with Behcet Disease without Active Inflammation

Authors
Chung, YR; Cho, EH; Jang, S; Lee, SY; Lee, ES; Lee, K
Citation
Korean journal of ophthalmology : KJO, 32(4):290-295, 2018
Journal Title
Korean journal of ophthalmology : KJO
ISSN
1011-89422092-9382
Abstract
PURPOSE: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation.
METHODS: A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015. Subfoveal choroidal thickness was measured using EDI-OCT.
RESULTS: The NUBD group included 46 eyes in 24 patients; the IUBD group included 16 eyes in 11 patients; and the control group included 35 eyes in 23 individuals. The mean subfoveal choroidal thicknesses differed significantly among these groups. Choroidal thickness was significantly greater in the NUBD (310.5 ± 81.0 μm) than in the IUBD (263.1 ± 56.6 μm, p = 0.013) and control (256.9 ± 67.9 μm, p = 0.002) groups. The disease activity score was significantly higher in the NUBD than in the IUBD group (p < 0.001), while the use of cyclosporine was significantly associated with choroidal thickness in eyes with NUBD (p = 0.039).
CONCLUSIONS: Subfoveal choroidal thickness, as measured by EDI-OCT, may be a clinical indicator of subclinical ocular inflammation and systemic inflammation in BD patients without active ocular inflammation.
Keywords
Behcet syndromeChoroidal thicknessInflammation
MeSH terms
AdultBehcet Syndrome/diagnosis*Choroid/diagnostic imagingChoroid/pathology*FemaleHumansInflammation/diagnosisMaleMiddle AgedOrgan SizeRetrospective StudiesTomography, Optical CoherenceUveitis, Anterior/diagnosis*Uveitis, Posterior/diagnosis*
DOI
10.3341/kjo.2017.0139
PMID
30091307
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Ophthalmology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
정, 유리이, 은소이, 기황
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