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Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.

Authors
Kang, Y; Kim, JH; Lee, TH; Kim, TS; Jung, WH; Chung, HC; Park, BW; Sheen, SS; Han, JH
Citation
Human pathology, 40(1):98-107, 2009
Journal Title
Human pathology
ISSN
0046-81771532-8392
Abstract
The proteolytic destruction of cyclin B is an important event during cell division. Cyclin B proteolysis is triggered by the anaphase-promoting complex. Therefore, cell cycle dysregulation due to anaphase-promoting complex loss contributes to cell transformation and human carcinogenesis. This study investigates anaphase-promoting complex7 expression in spindle cell breast tumors and also includes a comparison between the proliferation antigen Ki-67 and S-phase fraction. The average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor. The frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors. The above results indicate that anaphase-promoting complex7 and Ki-67 are closely related to cell proliferation. In addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry. Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma.
MeSH terms
AdolescentAdultBreast Neoplasms/geneticsBreast Neoplasms/metabolism*Breast Neoplasms/pathologyChildChild, PreschoolFemaleFibroadenoma/geneticsFibroadenoma/metabolism*Fibroadenoma/pathologyFlow CytometryGene Expression Regulation, Neoplastic*HumansImmunohistochemistryKi-67 Antigen/metabolismMiddle AgedPhyllodes Tumor/geneticsPhyllodes Tumor/metabolism*Phyllodes Tumor/pathologyRetrospective StudiesS PhaseUbiquitin-Protein Ligase Complexes/geneticsUbiquitin-Protein Ligase Complexes/metabolism*Young Adult
DOI
10.1016/j.humpath.2008.04.023
PMID
18789487
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
강엽김장희신승수한재호
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