31 306

Cited 0 times in

High plasma concentration of remnant lipoprotein cholesterol in obese children and adolescents.

Authors
Choi, YJ; Jo, YE; Kim, YK; Ahn, SM; Jung, SH; Kim, HJ; Chung, YS; Lee, KW; Kim, DJ
Citation
Diabetes care, 29(10):2305-2310, 2006
Journal Title
Diabetes care
ISSN
0149-59921935-5548
Abstract
OBJECTIVE: Remnant lipoproteins (RLPs) are the products of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine. Recent studies have demonstrated that RLPs are correlated with cardiovascular risk. We assessed the relationship between obesity and RLP and evaluated the factors related to RLP in children and adolescents.



RESEARCH DESIGN AND METHODS: We measured BMI, waist circumference, blood pressure, body fat mass, total abdominal fat, visceral and subcutaneous fat areas, fasting glucose, insulin, total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, and RLP cholesterol in 135 children and adolescents (67 boys and 68 girls). Plasma RLP fractions were isolated using an immunoaffinity gel containing specific anti-apolipoprotein (apo) B-100 and anti-apoA-I antibodies. Based on the BMI percentile, the subjects were divided into two groups: normal (< 85th percentile) and overweight (> or = 85th percentile).



RESULTS: RLP cholesterol was significantly correlated with age, sex, BMI, waist circumference, systolic and diastolic blood pressures, visceral and subcutaneous fat areas, visceral-to-subcutaneous fat area ratio, total cholesterol, triglycerides, HDL cholesterol, apoB, and homeostasis model assessment of insulin resistance (HOMA-IR). According to the multivariate regression analysis, triglycerides (beta = 0.928, P < 0.001) were independently correlated with RLP cholesterol. After excluding lipid profiles as an independent variable, the multivariate regression analysis revealed that HOMA-IR (beta = 0.231, P = 0.007) and systolic blood pressure (beta = 0.169, P = 0.046) were independently associated with RLP cholesterol.



CONCLUSIONS: RLP cholesterol was significantly higher in obese children and adolescents. Triglycerides, systolic blood pressure, and insulin resistance were related to RLP cholesterol.
MeSH terms
Abdominal Fat/anatomy & histologyAdolescentApolipoprotein B-100/bloodBlood PressureBody Mass IndexChildCholesterol, VLDL/blood*FemaleHomeostasis/physiologyHumansInsulin Resistance/physiologyIntra-Abdominal Fat/anatomy & histologyKoreaMaleMultivariate AnalysisObesity/blood*Subcutaneous Fat/anatomy & histologyTriglycerides/blood
DOI
10.2337/dc06-0938
PMID
17003311
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김, 연경안, 상미정, 선혜김, 혜진정, 윤석이, 관우김, 대중
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse