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Trajectories of health-related quality of life in breast cancer patients

Park, JH  | Jung, YS  | Kim, JY  | Jo, Y | Bae, SH
Supportive care in cancer, 28(7). : 3381-3389, 2020
Journal Title
Supportive care in cancer
PURPOSE: The purpose of this study was to explore the trajectory of health-related quality of life (HRQoL) and its predictors in breast cancer patients.

METHODS: A total of 126 women with newly diagnosed breast cancer provided baseline sociodemographic and medical characteristics and then completed an HRQoL questionnaire along with self-report measures of anxiety, depression, and cancer-related fatigue prior to their first cycle of chemotherapy (baseline), after chemotherapy completion, and at 6, and 12 months after chemotherapy completion. Group-based trajectory models were constructed to identify HRQoL trajectories over time. Logistic regression analysis was used to evaluate predictors of HRQoL in distinct patient groups.

RESULTS: Group-based trajectory modeling classified two patient groups: participants with consistently medium overall HRQoL trajectories (41.1%) and participants with consistently low overall HRQoL trajectories (58.9%). Older age, perceived severe economic burden, and higher depression predicted consistently low overall HRQoL through 12 months after chemotherapy.

CONCLUSIONS: Less than half of the total number of patients maintained a medium level of overall HRQoL after diagnosis and treatment of breast cancer, and nearly 60% continued to have lower overall HRQoL even after the treatment was complete. Older participants with more severe economic burden and higher depression experienced lower and more persistent overall HRQoL; thus, these patients should be monitored and provided supportive care as a part of survivorship care.


Appears in Collections:
Journal Papers > College of Nursing Science / Graduate School of Nursing Sciences > Nursing Science
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
김, 지영  |  박, 진희  |  배, 선형  |  정, 용식
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