Neurotoxic effect of occupational exposure to mixed organic solvents in Korea: Posturographic study.

Abstract

BACKGROUND: This study used static posturography to investigate the neurotoxic effects on workers exposed to mixed organic solvents at low concentrations under the levels of the threshold limit values (TLV).

METHODS: Forty-one workers from four plants exposed to mixed solvents and 90 non-exposed referents were examined. The lifetime cumulative biological exposure (CE) was estimated according to subject's occupational history and biological monitoring results. Static posturography and questionnaire were the basis of data collection.

RESULTS: The mean exposure index of mixed organic solvents of four plants was 0.47 (SD: 0.33, range: 0.08-1.39). The exposed group showed a larger sway area and length under the eye open condition than did the non-exposed group. In a multiple linear regression, a significant positive association was demonstrated between postural sway area and CE.

CONCLUSIONS: This study results suggest that the exposure to organic solvents under TLV levels may cause disturbance in postural stability.