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The course of patients with lacunar infarcts and a parent arterial lesion: similarities to large artery vs small artery disease.

Bang, OY; Joo, SY; Lee, PH; Joo, US; Lee, JH; Joo, IS; Huh, K
Archives of neurology, 61(4):514-519, 2004
Journal Title
Archives of neurology
BACKGROUND: The significance of occlusive lesions of the parent artery in patients with lacunar syndrome (LS) and small deep infarcts (SDIs) on diffusion-weighted imaging remains unclear.

OBJECTIVE: To compare the recurrence of stroke in patients with LS and SDIs between those with vs without a parent arterial lesion.

DESIGN: Analysis of data from a prospective acute stroke registry.

SETTING: University hospital.

PATIENTS: Using clinical syndrome, diffusion-weighted imaging, and vascular studies, we divided 173 patients into 3 groups: (1) parent arterial disease occluding deep perforators (PAD), LS with SDIs, and a parent arterial lesion (n = 32); (2) small artery disease (SAD) (n = 70); and (3) large artery disease (LAD) (n = 71).

MAIN OUTCOME MEASURES: Recurrent strokes and the prognosis were registered for 1 year, and the outcome of the PAD group was compared with that of the SAD and LAD groups.

RESULTS: During follow-up, there were 9 deaths (6 vascular) and 18 recurrent strokes. The recurrence rate in the PAD group (16%) was significantly higher than that in the SAD group (1%) (P =.01) but similar to that in the LAD group (17%) (P =.87). The presence of the parent arterial lesion was the only independent predictor of stroke recurrence in patients with LS and SDIs (odds ratio, 13.8; 95% confidence interval, 1.5-123.9; P =.02).

CONCLUSIONS: Although LS on examination, SDIs on diffusion-weighted imaging, and a stable hospital course suggest lacunar stroke of benign course, our results indicate that the PAD group represents an intracranial type of LAD.
MeSH terms
AdultAgedAged, 80 and overArterial Occlusive Diseases/*complications/diagnosis/mortalityBrain Infarction/diagnosis/*etiology/mortalityCerebral Arterial Diseases/*complications/diagnosis/mortalityDiagnosis, Differential*Diffusion Magnetic Resonance ImagingDominance, Cerebral/physiologyFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRecurrenceRisk FactorsSensitivity and SpecificitySurvival Rate
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
방, 오영이, 필휴주, 인수허, 균
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