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Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma.

Authors
Cho, DS; Joo, HJ; Oh, DK; Kang, JH; Kim, YS; Lee, KB; Kim, SJ
Citation
Yonsei medical journal, 46(1):133-140, 2005
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 and p53 expression with prognosis in patients with conventional renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 92 patients, who had undergone radical nephrectomy, were examined for COX-2 and p53 expression by immunohistochemistry and compared with clinicopathological variables. The COX-2 expression significantly correlated only with tumor size (p=0.049), whereas the p53 expression profoundly correlated with the TNM stage (p=0.024), M stage (p=0.001), and metastasis (synchronous or metachronous; p=0.004). The COX-2 overexpression did not significantly associate with p53 positivity (p=0.821). The survival rate of patients correlated with the p53 expression (p<0.0001) but not with the COX-2 expression (p=0.7506). Multivariate analyses indicated that tumor size, M stage, and p53 expression were independent prognostic factors for cancer-specific survival. The COX-2 expression was not an independent factor. These results show that the increased expression of p53 was associated with metastasis and a worse prognosis in conventional RCC, which suggests that p53 might have played an important role in the progression of conventional RCC. The increased expression of COX-2 was associated only with tumor size, but may not be an important prognostic factor in conventional RCC. No association was observed between COX-2 overexpression and p53 positivity in conventional RCC.
MeSH terms
Carcinoma, Renal Cell/metabolism*Carcinoma, Renal Cell/mortalityCarcinoma, Renal Cell/pathologyCyclooxygenase 2HumansKidney Neoplasms/metabolism*Kidney Neoplasms/mortalityKidney Neoplasms/pathologyMembrane ProteinsPrognosisProstaglandin-Endoperoxide Synthases/metabolism*Tumor Markers, Biological/metabolism*Tumor Suppressor Protein p53/metabolism*
DOI
10.3349/ymj.2005.46.1.133
PMID
15744816
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
주, 희재김, 영수이, 기범김, 세중
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