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Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer

Park, SS  | Lee, YK  | Choi, YW  | Lim, SB  | Park, SH | Kim, HK | Shin, JS | Kim, YH  | Lee, DH | Kim, JH  | Park, TJ
Cell reports, 43(3). : 113912-113912, 2024
Journal Title
Cell reports
In this study, we explore the dynamic process of colorectal cancer progression, emphasizing the evolution toward a more metastatic phenotype. The term “evolution” as used in this study specifically denotes the phenotypic transition toward a higher metastatic potency from well-formed glandular structures to collective invasion, ultimately resulting in the development of cancer cell buddings at the invasive front. Our findings highlight the spatial correlation of this evolution with tumor cell senescence, revealing distinct types of senescent tumor cells (types I and II) that play different roles in the overall cancer progression. Type I senescent tumor cells (p16INK4A+/CXCL12+/LAMC2−/MMP7−) are identified in the collective invasion region, whereas type II senescent tumor cells (p16INK4A+/CXCL12+/LAMC2+/MMP7+), representing the final evolved form, are prominently located in the partial-EMT region. Importantly, type II senescent tumor cells associate with local invasion and lymph node metastasis in colorectal cancer, potentially affecting patient prognosis.


Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > Research Organization > Inflamm-aging Translational Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Ajou Authors
김, 영화  |  김, 장희  |  박, 순상  |  박, 태준  |  이, 영경  |  임, 수빈  |  최, 용원
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