Detection of differential proteomes of human beta-cells during islet-like differentiation using iTRAQ labeling.
Jin, J; Park, J; Kim, K; Kang, Y; Park, SG; Kim, JH; Park, KS; Jun, H; Kim, Y
Journal of proteome research, 8(3):1393-1403, 2009
Journal of proteome research
A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release.
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