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Detection of differential proteomes of human beta-cells during islet-like differentiation using iTRAQ labeling.

Authors
Jin, J; Park, J; Kim, K; Kang, Y; Park, SG; Kim, JH; Park, KS; Jun, H; Kim, Y
Citation
Journal of proteome research, 8(3):1393-1403, 2009
Journal Title
Journal of proteome research
ISSN
1535-38931535-3907
Abstract
A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release.
MeSH terms
Cell Differentiation/physiology*Cell LineChromatography, LiquidHumansInsulin/biosynthesisInsulin-Secreting Cells/cytologyInsulin-Secreting Cells/physiology*Isotope LabelingProteome/metabolism*RNA, Messenger/metabolismTandem Mass Spectrometry
DOI
10.1021/pr800765t
PMID
19199707
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
강엽
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