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Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice.

Authors
Mook-Jung, I; Hong, HS; Boo, JH; Lee, KH; Yun, SH; Cheong, MY; Joo, I; Huh, K; Jung, MW
Citation
Journal of neuroscience research, 63(6):509-515, 2001
Journal Title
Journal of neuroscience research
ISSN
0360-40121097-4547
Abstract
We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses.
MeSH terms
AnimalsCentral Nervous System Agents/pharmacology*Cognition/drug effectsElectrophysiologyGinsenosidesHippocampus/drug effectsHippocampus/metabolism*Long-Term Potentiation/drug effectsMaze Learning/drug effects*Memory/drug effectsMiceMice, Inbred C57BLSaponins/pharmacology*Space Perception/drug effectsSynapses/drug effectsSynapses/physiologySynaptophysin/metabolism*
DOI
10.1002/jnr.1045
PMID
11241586
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
묵, 인희주, 인수허, 균정, 민환
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