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Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.

Authors
Tada, A; Suzuki, I; Im, S; Davis, MB; Comelius, J; Babcock, G; Nordlund, JJ; Abdel-Malek, ZA
Citation
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 9(7):575-584, 1998
Journal Title
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
ISSN
1044-9523
Abstract
Endothelin (ET)-1, alpha-melanocyte stimulating hormone (alpha-melanotropin; alpha-MSH), and basic fibroblast growth factor (bFGF) are keratinocyte-derived factors that interact synergistically to stimulate human melanocyte proliferation. ET-1 has a dose-dependent mitogenic effect on human melanocytes and a biphasic effect on melanogenesis: a stimulatory effect at subnanomolar concentrations, and an inhibitory effect at concentrations equal to or higher than 1 nM. Human melanocytes express ET B receptors. Brief treatment of melanocytes with ET-1 caused up-regulation of alpha-MSH receptor mRNA but did not alter ET B receptor mRNA level. ET-1 modulates the response of human melanocytes to UV rays (UVRs). Treatment of melanocytes with 10 nM ET-1 immediately after exposure to UVRs enabled them to overcome the G1 growth arrest. However, ET-1 did not inhibit p53 accumulation or p21(Waf-1/SDI-1/Cip-1) overexpression, nor did it reverse the hypophosphorylated state of pRb or the reduction in Bcl2 level in irradiated melanocytes. These results substantiate the role of ET-1 as a paracrine regulator that modulates the response of human melanocytes to UVRs.
MeSH terms
Cell Division/physiologyCells, CulturedDose-Response Relationship, DrugEndothelin-1/*physiologyEndothelin-3/physiologyGene Expression RegulationGenes, bcl-2/physiologyHumansMelanocytes/cytology/*physiology/*radiation effectsMitogens/physiologyParacrine CommunicationRadiation ToleranceReceptor, Endothelin BReceptors, Corticotropin/metabolismReceptors, Endothelin/metabolismReceptors, MelanocortinTumor Suppressor Protein p53/geneticsUltraviolet Raysalpha-MSH/physiology
PMID
9690625
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
임, 성빈
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