106 245

Cited 0 times in

Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma

Other Title
신세포암에서 Tissue Microarray를 이용하여 분석한 Caveolin-1 발현과 예후와의 연관성
Authors
원, 용연; 주, 희재; 조, 대성; 서, 경식; 안, 병철; 김, 기훈; 김, 세중
Citation
Taehan Pinyogikwa Hakhoe chi, 47(6):607-613, 2006
Journal Title
Taehan Pinyogikwa Hakhoe chi; The Korean journal of urology; 대한비뇨기과학회지
ISSN
0494-4747
Abstract
Purpose: We investigated the relationship between the expression of caveolin-1, using a tissue microarray(TMA), and the prognosis of patients with renal cell carcinoma(RCC).



Materials and Methods: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables.



Results: The expression of caveolin-1 was significantly correlated with tumor size(p=0.002), TNM stage(p<0.001), T stage(p=0.001), M stage (p=0.004), grade(p=0.028) and metastasis(p<0.001), and was also significantly higher in clear cell than non-clear cell RCC(p<0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression(p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor.



Conclusions: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC.
Keywords
Caveolin-1Tissue microarrayPrognosisRenal cell carcinoma
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
원, 용연주, 희재조, 대성안, 병철김, 세중
Full Text Link
Files in This Item:
607-613.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse