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Role of HPV DNA testing for detection of high-grade cervical lesions in women with atypical squamous cells of undetermined significance: a prospective study in a Korean population.

Authors
Yoon, JH; Yoo, SC; Kim, WY; Chang, SJ; Chang, KH; Ryu, HS
Citation
European journal of gynaecological oncology, 30(3):271-274, 2009
Journal Title
European journal of gynaecological oncology
ISSN
0392-2936
Abstract
OBJECTIVE: The purpose of this study was to determine if HPV DNA testing improves the accuracy of detecting possible high-grade cervical lesions in women with atypical squamous cells of undetermined significance (ASC-US). METHODS: Cervical cytology and Hybrid Capture II (HCII) assay for HPV DNA detection was performed in 10,526 women from July 2005 to July 2007. Two hundred and sixty women with ASC-US underwent colposcopy-directed biopsy to determine the final histologic diagnosis. They were divided into two groups according to the positivity of the HPV DNA test, and the respective biopsy results were compared. RESULTS: Positive HCII was significantly more associated with CIN 2, CIN 3, and invasive cancer than negative HCII (p < 0.001). The odds ratio of positive HPV DNA testing in detecting high-grade lesions was 7.0 (95% CI; 2.8-17.7). CONCLUSION: The HPV DNA test is useful for predicting the severity of lesions of the uterine cervix and formulating decisions with regard to treatment plans.
MeSH terms
AdultCarcinoma, Squamous Cell/diagnosis*Carcinoma, Squamous Cell/virologyCervical Intraepithelial Neoplasia/diagnosis*Cervical Intraepithelial Neoplasia/virologyCytodiagnosisDNA, Viral/analysis*FemaleHumansMiddle AgedPapillomaviridae/geneticsPapillomaviridae/isolation & purification*Papillomavirus Infections/diagnosis*Predictive Value of TestsROC CurveSensitivity and SpecificityUterine Cervical Neoplasms/diagnosis*Uterine Cervical Neoplasms/virologyVaginal Smears
PMID
19697619
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
윤종혁유승철김우영장석준장기홍유희석
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