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TRAPc as a Marker of Antioxidant System in Korean Type 2 Diabetic Patients

Other Title
제2형 당뇨병 환자의 혈장 총항산화 방어체계의 지표로서TRAPc(Total radical trapping antioxidant parameter, calculated)
Authors
이, 관우; 하, 애화; 김, 현만
Citation
Journal of Korean Society of Endocrinology, 14(1):134-141, 1999
Journal Title
Journal of Korean Society of Endocrinology; 대한내분비학회지
ISSN
1015-6380
Abstract
Background: It has been suggested that diabetic patients are under high oxidative

stress and plasma MDA concentration is a reliable marker for oxidative stress. However, some studies showed that plasma MDA is not a good marker for oxidative stress.

Recently, the total radical-trapping antioxidant parameter (TRAPc) has been proposed as a marker for the overall antioxidant property of plasma samples. Therefore, in this study, we tried to evaluate whether MDA and TRAPc are reliable markers of the oxidative stress-antioxidant system or not.

Methods: The plasma samples from 67 type 2 diabetic patients and 31 normal subjects

were collected. The plasma MDA, protein-bound SH groups, uric acid and vitamin C

were determined by fluorophotometry or spectrophotometry. Plasma vitamin I

concentration was analyzed by HPLC. Calculated TRAP (TRAPc) were determined by

the proposed calculation methods.

Results : 1. Diabetic patients had significantly lower TRAPc, compared with normal subjects.

2. SH groups, uric acid, vitamin C and vi拉min I were not different between the two

groups.

3. MDA and MDA/TG were significantly higher in diabetic subjects.

Conclusion : From the results of this study, TRAPc seems to be a reliable parameter

of overall plasma antioxidant system and the plasma MDA may be used as a marker of

oxidative stress, but further long-term logitudinal studies are needed.
Keywords
DiabetesOxidativeStressVitamins
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Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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