Journal of Korean Society of Endocrinology, 14(1):134-141, 1999
Journal of Korean Society of Endocrinology; 대한내분비학회지
Background: It has been suggested that diabetic patients are under high oxidative
stress and plasma MDA concentration is a reliable marker for oxidative stress. However, some studies showed that plasma MDA is not a good marker for oxidative stress.
Recently, the total radical-trapping antioxidant parameter (TRAPc) has been proposed as a marker for the overall antioxidant property of plasma samples. Therefore, in this study, we tried to evaluate whether MDA and TRAPc are reliable markers of the oxidative stress-antioxidant system or not.
Methods: The plasma samples from 67 type 2 diabetic patients and 31 normal subjects
were collected. The plasma MDA, protein-bound SH groups, uric acid and vitamin C
were determined by fluorophotometry or spectrophotometry. Plasma vitamin I
concentration was analyzed by HPLC. Calculated TRAP (TRAPc) were determined by
the proposed calculation methods.
Results : 1. Diabetic patients had significantly lower TRAPc, compared with normal subjects.
2. SH groups, uric acid, vitamin C and vi拉min I were not different between the two
3. MDA and MDA/TG were significantly higher in diabetic subjects.
Conclusion : From the results of this study, TRAPc seems to be a reliable parameter
of overall plasma antioxidant system and the plasma MDA may be used as a marker of
oxidative stress, but further long-term logitudinal studies are needed.
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