0 183

Cited 0 times in

Localization of transforming growth factor β1 in airway mucosa of toluene diisocyanate-induced asthma

Other Title
Toluene diisocyanate에 의한 천식 환자의 기도 점막내 transforming growth factor β1의 발현 양상
Authors
이, 수걸; 이, 선민; 함, 기백; 임, 현이; 박, 충식; 김, 선신; 남, 동호; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 21(3):500-507, 2001
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background and objective: There have been some reports on the expression of TGF β-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF β1 in bronchial mucosa of TDI-induced asthma is not

known.

The aim of this study was to observe immunolocalization of TGF β1 in airway mucosa of TDI-induced asthma.

Methods: TGF β1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I: 10 newly diagnosed, group II: 12 subjects with persistent asthma symptoms for more than 4 years after

diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM),

and

mucous glands(MG).

Results: Positive rates of TGF β1 expression for groups Ⅰ and Ⅱ in the four areas were as follows; EP (50% vs 100%, p<0.05), VE(40% vs 100%, p<0.05), SM(33.3% vs 100%, p0.05). Grades of TGF β1 expression of EP,

VE, and

SM were significantly higher in group II than in group I(p0.05, respectively).

Conclusion: TGF β1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
Keywords
Localization of TGF β1bronchial mucosaTDI-induced asthma
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse