Topical Photodynamic Therapy for Treatment of Actinic Keratosis Using Light-Emitting Diode (LED) Device
광선각화증에서 Light-Emitting Diode (LED)를 이용한 국소 광역동요법의 치료효과
이, 중선; 김, 윤전; 강, 희영; 이, 은소; 오, 충훈; 김, 유찬
Korean journal of dermatology, 43(4):469-474, 2005
Korean journal of dermatology; 대한피부과학회지
Background: Photodynamic therapy is a treatment modality which involves the sequential administration of a photosensitizer and light. Topical photodynamic therapy is being increasingly used for superficial non-melanoma skin cancers and their precursors.
Objective: The purpose of this study was to evaluate the effectiveness and side effects of treating actinic keratosis with photodynamic therapy using a light-emitting diode device and 20% 5-aminolevulinic acid.
Methods: Photodynamic therapy, with a 630+/-50nm light-emitting diode device and 5-aminolevulinic acid, was used to treat 12 lesions of actinic keratosis on 8 patients. The light intensity used was 50mW/cm2 , and the light dose was 100-120J/cm2 . Four weeks after 1 or 2 treatment sessions, the outcome was evaluated by histopathological findings.
Results: Complete clearance was achieved in 8 of 12 lesions after a single treatment, and in 3 of 12 lesions after 2 treatment sessions. Only 1 case showed partial response after 2 treatment sessions. Only 2 patients suffered from a stinging sensation when exposed to the light therapy.
Conclusion: Topical photodynamic therapy using a light-emitting diode is safe and effective in the treatment of actinic keratosis.
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