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Immunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non-granulomatous rosacea.

Authors
Jang, YH; Sim, JH; Kang, HY; Kim, YC; Lee, ES
Citation
Journal of the European Academy of Dermatology and Venereology : JEADV, 25(5):544-548, 2011
Journal Title
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN
0926-99591468-3083
Abstract
BACKGROUND: There is a granulomatous variant which is recognized in the rosacea spectrum. However, the pathogenesis of granuloma formation in rosacea has not been clearly demonstrated. Matrix metalloproteinases (MMPs) are required for recruitment of inflammatory cells and for tissue remodelling, making way for the development of well-organized granuloma.



OBJECTIVE: The aim of this study was to investigate the expression of transforming growth factor (TGF)-β, TGF-β type II receptor (TβRII), Tumour necrosis factor (TNF)-α, MMP-1, 2 and 9 in the granulomatous rosacea (GR) compared with the non-granulomatous rosacea (NGR) and test the hypothesis that the changes of these profiles in GR would be related with chronic ultraviolet radiation (UVR)-exposure.



METHODS: Facial skin samples were obtained from 20 patients with GR and NGR (control group). The sections were stained using haematoxylin and eosin, Verhoeff's elastic stain, and antibodies to TGF-β, TβRII, TNF-α, MMP-1, -2 and -9.



RESULTS: The amount of elastotic material was significantly increased in the dermis of GR lesions. Expression of TGF-β was significantly decreased in the epidermis of GR lesions compared with NGR lesions. In addition, the expression of MMP-9 was significantly increased in the dermis of GR lesions compared with NGR lesions, especially at the centre of the granuloma on a semi-quantitative analysis. MMP-2 expression was also increased in GR lesions, although the difference between the two groups was not statistically significant.



CONCLUSIONS: The results of this study suggest that the increased expression of MMPs in the dermis may participate in granuloma formation of GR in association with UVR.
MeSH terms
AdultCase-Control StudiesEnvironmental Exposure/adverse effectsFacial Dermatoses/*metabolismFemaleHumansMaleMatrix Metalloproteinase 1/*metabolismMatrix Metalloproteinase 2/*metabolismMatrix Metalloproteinase 9/*metabolismMiddle AgedProtein-Serine-Threonine Kinases/metabolismReceptors, Transforming Growth Factor beta/metabolismRosacea/etiology/*metabolismSkin/metabolism/radiation effectsTime FactorsTransforming Growth Factor beta/metabolismTumor Necrosis Factor-alpha/metabolismUltraviolet Rays/*adverse effectsYoung Adult
DOI
10.1111/j.1468-3083.2010.03825.x
PMID
20698913
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
강, 희영김, 유찬이, 은소
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