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Transcriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.

Authors
Kang, HY; Suzuki, I; Lee, DJ; Ha, J; Reiniche, P; Aubert, J; Deret, S; Zugaj, D; Voegel, JJ; Ortonne, JP
Citation
The Journal of investigative dermatology, 131(8):1692-1700, 2011
Journal Title
The Journal of investigative dermatology
ISSN
0022-202X1523-1747
Abstract
Melasma is a commonly acquired hyperpigmentary disorder of the face, but its pathogenesis is poorly understood and its treatment remains challenging. We conducted a comparative histological study on lesional and perilesional normal skin to clarify the histological nature of melasma. Significantly, higher amounts of melanin and of melanogenesis-associated proteins were observed in the epidermis of lesional skin, and the mRNA level of tyrosinase-related protein 1 was higher in lesional skin, indicating regulation at the mRNA level. However, melanocyte numbers were comparable between lesional and perilesional skin. A transcriptomic study was undertaken to identify genes involved in the pathology of melasma. A total of 279 genes were found to be differentially expressed in lesional and perilesional skin. As was expected, the mRNA levels of a number of known melanogenesis-associated genes, such as tyrosinase, were found to be elevated in lesional skin. Bioinformatics analysis revealed that the most lipid metabolism-associated genes were downregulated in lesional skin, and this finding was supported by an impaired barrier function in melasma. Interestingly, a subset of Wnt signaling modulators, including Wnt inhibitory factor 1, secreted frizzled-related protein 2, and Wnt5a, were also found to be upregulated in lesional skin. Immunohistochemistry confirmed the higher expression of these factors in melasma lesions.
MeSH terms
Adaptor Proteins, Signal Transducing/genetics/metabolismAdultFrizzled Receptors/genetics/metabolism*Gene Expression ProfilingHumansImmunohistochemistryIn Situ HybridizationLipid Metabolism/*geneticsMelanocytes/physiologyMelanosis/*genetics/*metabolism/pathologyMembrane Glycoproteins/genetics/metabolismMiddle AgedOxidoreductases/genetics/metabolismProto-Oncogene Proteins/genetics/metabolismReceptors, G-Protein-Coupled/genetics/metabolismRepressor Proteins/genetics/metabolismWnt Proteins/*genetics/*metabolismWnt1 Protein/genetics/metabolism
DOI
10.1038/jid.2011.109
PMID
21562572
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
강, 희영
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