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Perfluorooctanoic acid exposure is associated with elevated homocysteine and hypertension in US adults

Min, JY; Lee, KJ; Park, JB; Min, KB
Occupational and environmental medicine, 69(9):658-662, 2012
Journal Title
Occupational and environmental medicine
OBJECTIVE: To investigate the association between serum perfluorooctanoic acid (PFOA) concentration and cardiovascular disease, as measured by homocysteine level and blood pressure in a representative sample of US adults.

METHODS: A cross-sectional study of 2934 adults (≥20 years) who participated in the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey and had detectable levels of PFOA in their serum. The health effects analysed as potentially associated with PFOA exposure included homocysteine level and blood pressure.

RESULTS: The geometric mean value (95% CI) of the study participants' serum PFOA concentration was 4.00 μg/l (95% CI 3.86 to 4.13). The homocysteine and systolic blood pressure were shown to increase significantly with an increase in the log-transformed serum PFOA concentration, after adjusting for potential confounding variables. Adjusted ORs comparing participants at the 80th versus the 20th percentiles were 2.62 for hypertension (95% CI 2.09 to 3.14), and a positive association was also evident in models based on quartiles or based on restricted cubic splines.

CONCLUSION: These findings suggest that background exposure to PFOA may continue a risk factor for the development of cardiovascular diseases.
MeSH terms
AdultBlood Pressure/*drug effectsCaprylates/*adverse effects/bloodCross-Sectional StudiesEnvironmental Exposure/*adverse effectsFemaleFluorocarbons/*adverse effects/bloodHazardous Substances/*adverse effects/bloodHomocysteine/*bloodHumansHyperhomocysteinemia/blood/*etiologyHypertension/blood/*etiologyMaleMiddle AgedNutrition SurveysOdds RatioRisk FactorsUnited StatesYoung Adult
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Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
AJOU Authors
이, 경종박, 재범민, 경복
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