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Correlation of Cyclooxygenase-2 Expression and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract

Other Title
상부요로 이행세포암에서 Cyclooxygenase-2 발현 및 미세혈관 밀도와 예후와의 연관성
Authors
차, 민호; 조, 대성; 임, 현이; 조, 강수; 홍, 성준; 조, 남훈; 김, 선일; 안, 현수; 김, 세중
Citation
Taehan Pinyogikwa Hakhoe chi, 48(4):376-382, 2007
Journal Title
Taehan Pinyogikwa Hakhoe chi; The Korean journal of urology; 대한비뇨기과학회지
ISSN
0494-4747
Abstract
Purpose: The aim of this study was to investigate the relationship of cyclooxygenase(COX)-2 expression and microvessel density(MVD), a reflection of angiogenesis, with prognosis in patients with transitional cell carcinoma of the upper urinary tract(TCC-UUT).



Materials & Methods: Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 91 patients, who had undergone radical nephroureterectomy, were examined immunohistochemically using antibodies against COX-2 and CD34. MVD was determined with CD34-stained slides. The expression patterns of COX-2 and MVD were compared with the clinicopathological variables.



Results: The COX-2 expression was significantly correlated with T stage (p=0.002), N stage(p=0.010), and grade(p=0.027). MVD was also significantly correlated with T stage(p<0.001), N stage(p=0.002), and grade (p=0.001). The COX-2 expression was significantly correlated with MVD (p=0.001). The survival rate of patients with COX-2 positive tumors or high MVD was significantly lower than that of patients with COX-2 negative tumors or low MVD, respectively(p=0.0013, p=0.0312). Univariate analyses identified T stage, N stage, grade, COX-2 expression, and MVD as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that T stage was the only independent prognostic factor.



Conclusion: The increased expression of COX-2 and MVD is associated with a worse prognosis in TCC-UUT. The COX-2 expression is correlated with MVD. These results suggest that COX-2 may play an important role in the progression of TCC-UUT and angiogenesis may be affected by COX-2 during the progression of TCC-UUT.
Keywords
Cyclooxygenase 2PrognosisTransitional cell carcinomaUrinary tract
DOI
10.4111/kju.2007.48.4.376
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
임, 현이김, 선일안, 현수김, 세중
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