139 274

Cited 32 times in

Prognostic significance of the micropapillary pattern in patients with serous borderline ovarian tumors.

Authors
Chang, SJ; Ryu, HS; Chang, KH; Yoo, SC; Yoon, JH
Citation
Acta obstetricia et gynecologica Scandinavica, 87(4):476-481, 2008
Journal Title
Acta obstetricia et gynecologica Scandinavica
ISSN
0001-63491600-0412
Abstract
BACKGROUND: The impact of micropapillary histology on survival in patients with serous borderline ovarian tumors is not established. The purpose of this study was to evaluate the significance and influence of micropapillary pattern on clinical outcome of patients with serous borderline ovarian tumors. METHODS: Eighty-five patients who underwent surgery and were diagnosed with serous borderline ovarian tumors were retrospectively studied. Among these patients, 18 patients showed micropapillary pattern on histologic examination, while the remaining 67 patients did not. The significance of the presence of micropapillary pattern and relationship with various clinicopathologic findings and progression-free survival were evaluated by statistical analysis. RESULTS: No differences with regard to age, parity, body mass index, pretreatment CA-125 level, tumor size, bilaterality, and the duration of follow-up were observed between the two groups, but there was a significant difference in terms of FIGO stage (p<0.001), invasive implants (p=0.004), performing lymphadenectomy (p=0.009), operation time (p=0.003), estimated blood loss (p<0.001), residual disease>1 cm (p=0.001), adjuvant chemotherapy (p<0.001), and the length of hospital stay (p=0.013). Progression-free survival was found to be significantly decreased in patients with invasive implants (HR, 5.06; p=0.025) and micropapillary pattern (HR, 4.20; p=0.056) on multivariate analysis. CONCLUSIONS: Micropapillary serous borderline ovarian tumors were associated with a more aggressive clinical course compared with typical serous borderline ovarian tumor. The presence of invasive implants and micropapillary pattern were significant prognostic factors in patients with serous borderline ovarian tumors.
MeSH terms
AdolescentAdultAgedDisease ProgressionFemaleHumansLength of StayLymph Node ExcisionMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOvarian Neoplasms/diagnosisOvarian Neoplasms/mortality*Ovarian Neoplasms/pathology*PrognosisRetrospective Studies
DOI
10.1080/00016340801995640
PMID
18382877
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
장석준유희석장기홍유승철윤종혁
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse