Uterine Leiomyosarcoma : 14-year Two-center Experience of 31 Cases
Kim, WY; Chang, SJ; Chang, KH; Yoon, JH; Kim, JH; Kim, BG; Bae, DS; Ryu, HS
Cancer research and treatment : official journal of Korean Cancer Association, 41(1):24-28, 2009
Cancer research and treatment : official journal of Korean Cancer Association
Purpose:The aim of this study was to evaluate the clinicopathological characteristics of uterineleiomyosarcoma (LMS) and possible prognostic factors.
Materials and Methods:This study included 31 patients with histologically proven LMS at Samsung Medical Centerand Ajou University Hospital between 1994 and 2007. The medical records and availablehistological slides were reviewed retrospectively.
Results:The median age was 46 years (range, 32∼63). The most common symptom was vaginalbleeding (11 patients, 35.5%). There were 23 patients with stage I, one patient with stage III,seven patients with stage IV disease. The median follow up time was 29 months (range, 1∼94). The most common recurrence site was lung (5 case), followed by pelvis and upperabdomen (2 case). Nine patients died of disease with a 5-year overall survival rate of 63%.Early tumor stage and mitotic count were the prognostic factor in univariate analysis(p<0.0001 and p=0.0031, respectively), but early tumor stage only was associated withprognosis in multivariate analysis (p=0.010 vs p=0.143). Adjuvant treatment for early stagedisease did not decrease the recurrence rate (p=0.1075), but high mitotic count (15>10HPF)had a trend for disease recurrence in early stage LMS (p=0.0859).
Conclusion:Mitotic count less than 15/HPF in early stage may be related with longer progression-freeinterval, but we could not reach the conclusion that adjuvant therapy in early stage LMS beeffective.
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