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Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy.

Authors
Yoo, SC; Kim, WY; Yoon, JH; Chang, SJ; Chang, KH; Ryu, HS
Citation
Acta obstetricia et gynecologica Scandinavica, 89(1):126-130, 2010
Journal Title
Acta obstetricia et gynecologica Scandinavica
ISSN
0001-63491600-0412
Abstract
Abstract Objective. To evaluate the long-term outcome and ovarian function in premenarchal and adolescent patients with malignant ovarian germ cell tumors after fertility-preserving surgery and adjuvant chemotherapy. Design. Retrospective review of medical records. Setting. Ajou University Hospital, a tertiary care hospital in South Korea. Population. Forty-five patients with malignant ovarian germ cell tumors. Methods. A retrospective analysis of patients with malignant ovarian germ cell tumors was conducted and a statistical analysis was performed. Main outcome measures. There were 9 premenarchal and 16 adolescent patients; the median ages at diagnosis were 7 and 18 years, respectively. All patients were treated with fertility-preserving surgery. Seventeen of the patients received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (68.0%). There were no disease recurrences or deaths. Of the nine premenarchal patients, eight (88.9%) subsequently had normal menarche. Among the 16 adolescent patients, 15 (93.8%) resumed normal menstruation and 1 had premature ovarian failure. Conclusion. Premenarchal and adolescent patients with malignant ovarian germ cell tumors have excellent survival with fertility-preserving surgery and adjuvant chemotherapy. The majority of these patients can have normal menarche and menstruation.
MeSH terms
AdolescentAntineoplastic Combined Chemotherapy Protocols/therapeutic useChemotherapy, AdjuvantChildChild, PreschoolFemaleHumansLymph Node Excision*Menarche*MenstruationNeoplasms, Germ Cell and Embryonal/blood/drug therapy/*physiopathology/surgeryOvarian Neoplasms/blood/drug therapy/*physiopathology/surgeryRetrospective StudiesTeratoma/drug therapy/surgeryTumor Markers, Biological/blood
DOI
10.3109/00016340903348383
PMID
19878051
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
AJOU Authors
유, 승철김, 우영윤, 종혁장, 석준장, 기홍유, 희석
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