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Augmented eradication rates of Helicobacter pylori by new combination therapy with lansoprazole, amoxicillin, and rebamipide.

Authors
Hahm, KB; Lee, KJ; Kim, YS; Kim, JH; Cho, SW; Yim, H; Joo, HJ
Citation
Digestive diseases and sciences, 43(2):235-240, 1998
Journal Title
Digestive diseases and sciences
ISSN
0163-21161573-2568
Abstract
The aim of the present study was to determine the efficacy of a new combination regimen including an antioxidant, a proton pump inhibitor, and antibiotics against Helicobacter pylori and to document the changes of oxidative stress and cytokines involved in H. pylori-associated gastric inflammation. From 57 patients with endoscopically diagnosed gastric and/or duodenal ulcers associated with H. pylori infection five gastric antral biopsy specimens were taken for the diagnosis of H. pylori and for the experimental measures. The patients were then treated either with lansoprazole 30 mg + amoxicillin 1.5 g (LA group; 21 patients) or lansoprazole 30 mg + amoxicillin 1.5 g + rebamipide 300 mg (LAM group; 36 patients) for two weeks. Four weeks after the initiation of treatment, the patients were endoscoped again and biopsy specimens were obtained. Mucosal malondialdehyde (MDA) levels; myeloperoxidase (MPO) activities; superoxide dismutase; catalase; glutathione peroxidase; cytokines IL-1, IL-6, TNF-alpha; and chemokines IL-8, GRO-alpha, RANTES (regulated on activation normal T expressed and secreted) were measured. Using paraffin-embedded tissue sections, in situ terminal deoxyribonucleotide transferase (TdT) mediated dUTP nick end labeling (TUNEL) for apoptosis and immunohistochemical staining for inducible nitric oxide synthase (iNOS) were performed. Two weeks of treatment with the LA regimen resulted in 57.4% eradication rates of H. pylori, whereas two weeks of treatment with the LAM regimen resulted in 75.0% eradication rates. Eradication rates between these two groups were statistically significantly different (P < 0.05). Mucosal MDA levels and MPO activities were significantly lower in the LAM group than the LA group. Mucosal levels of cytokines IL-1, IL-6, and TNF-alpha and of chemokines IL-8, GRO-alpha, and RANTES were all significantly decreased after the treatment of H. pylori, especially so in the LAM group. The apoptotic index and iNOS score were significantly reduced after the eradication of H. pylori. The addition of an antioxidative drug to the eradication regimen against H. pylori has advantages either in augmenting the eradication rates of H. pylori or in decreasing the oxidative stress and cytokines levels generated by H. pylori infection.
MeSH terms
2-PyridinylmethylsulfinylbenzimidazolesAdultAgedAlanine/*analogs & derivatives/therapeutic useAmoxicillin/*therapeutic useAnti-Infective Agents/*therapeutic useAnti-Ulcer Agents/*therapeutic useAntioxidants/*therapeutic useChemokines/analysisCytokines/analysisDrug Therapy, CombinationGastric Mucosa/metabolismHelicobacter Infections/*drug therapy/metabolismHumansMiddle AgedNitric Oxide Synthase/metabolismNitric Oxide Synthase Type IIOmeprazole/*analogs & derivatives/therapeutic usePenicillins/*therapeutic usePeptic Ulcer/drug therapy/*microbiologyProspective StudiesProton Pumps/*antagonists & inhibitorsQuinolones/*therapeutic use
PMID
9512112
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
함, 기백이, 광재김, 영수김, 진홍조, 성원임, 현이주, 희재
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