Cited 0 times in Scipus Cited Count

Prognostic Value of Tumor Angiogenesis and Microvascular Invasion in Renal Cell Carcinoma

Other Title
신세포암에서 종양 혈관형성 및 미세혈관침범의 예후적 가치
조, 대성  | 임, 현이  | 오, 동근 | 강, 지훈 | 김, 영수  | 김, 세중
Korean journal of urology, 47(2). : 111-117, 2006
Journal Title
Korean journal of urology
Purpose: This study was performed to evaluate the impact of microvessel density(MVD), a reflection of tumor angiogenesis, and microvascular invasion(MVI) on the prognosis of patients with renal cell carcinoma(RCC).

Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of RCC from 81 patients who had undergone radical nephrectomy were stained immunohistochemically for CD34, which decorate endothelial cells, in order to assess MVD and MVI. The immunostaining results of MVD and MVI were compared with the clinicopathological variables.

Results: Twenty-two patients had either synchronous or metachronous metastases and fourteen patients died during the follow-up. MVD was significantly correlated with only metastasis(synchronous or metachronous; p=0.020). MVI was significantly correlated with tumor size(p=0.005), TNM stage(p<0.001), T stage(p<0.001), M stage(p=0.001), and metastasis(synchronous or metachronous; p=0.007). MVD was not significantly associated with MVI(p=0.232). The survival rate of patients with higher MVD or MVI-positive tumors was significantly lower than that of patients with lower MVD or MVI-negative tumors, respectively(p<0.0001, p=0.0002). Multivariate analyses indicated that tumor size, M stage and MVI were independent prognostic factors for cancer-specific survival. MVD was not an independent factor.

Conclusions: MVD and MVI were associated with metastasis and a worse prognosis in RCC, which suggests that tumor angiogenesis and MVI may play an important role in the progression of RCC. MVI was an independent prognostic factor for cancer-specific survival.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Ajou Authors
김, 세중  |  김, 영수  |  임, 현이  |  조, 대성
Full Text Link
Files in This Item:
The Korean journal of urology_47(2)_111-117.pdfDownload


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.